DEFINING BIOLOGY THROUGH ENERGY

BioElectron is focused on electrons in biology. We understand how proteins and small molecules encode data using electrons to communicate and synchronize the over 1 billion chemical reactions that take place per second in each cell. This knowledge enables us to solve important problems that are beyond the reach of current approaches and tools.
Platform
BioElectron has built the first biological energy learning engine. We are combining biotech and tech tools to develop robust and predictive models of complex biological systems using unique data derived from electron-transfer chemical reactions in annotated biological systems.
Measure
Measure electron-transfer chemical reactions in annotated biological systems
Model
Model electron communication network common to biology
Predict
Predict the function of complex biological systems
Solutions
Solutions to valuable and important problems in the life science and technology business ecosystems
Solutions
Engineering solutions for diverse problems in complex biological systems based on the fundamental and common properties of biological energy.
Pharma
Therapeutics for diseases of bioenergetic etiology
Health
Bioactives for and metrics of healthy living & aging
Industrial
Optimization of enzymes and production organisms
Tech
Prediction of dynamic complex biological systems
Portfolio
Industry Application Compound/Test Stage
Pharma Mitochondrial Disease: Expanded Access BioE-743
Compassionate Use
Pharma Leigh Syndrome BioE-743
Phase 2B
Pharma RARS2 Syndrome BioE-743
Phase 2
Pharma NIH Undiagnosed Disease Program BioE-743
Phase 2
Pharma ALS BioE-589
Phase 2A
Pharma Parkinson's Disease: Mito/Idiopathic BioE-589
Phase 2A
Pharma Mitochondrial Complex I Deficiency BioE-445
Pre-clinical
Pharma/Consumer Skin: Aging & Inflammation BioE-857
Pre-clinical
Pharma Diabetes: Insulin Secretion BioE-050
Pre-clinical
Pharma Diabetes: Insulin Resistance BioE-206
Pre-clinical
Pharma Cancer BioE-068
Pre-clinical
Pharma NASH/NAFL BioE-059
Pre-clinical
Medical Food Antioxidant Deficiency: Chronic BioE-1633
Clinical
Medical Food Antioxidant Deficiency: Acute BioE-1633
Clinical
Tech Human Aging BioE-132FV1.0
Clinical
Tech Maternal & Fetal Health BioE-132FV1.0
Clinical
Industrial Glucose Production/Biofuels Feedstock BioE-161
Discovery
Industrial Protein Production BioE-890
Discovery
Team
Leadership Scientific Advisory Board Board of Directors Advisors
Guy Miller, MD, PhD
Chairman & CEO


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James Gibson, CPA
CFO


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Matthew Murphy, JD
General Counsel


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Phil Leonard, MBA, JD
VP, BD & Strategic Alliances


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Shannon Odam
VP, Human Ecosystem


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Thomas Dhumad, MBA
VP, Information Technology


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Wally Parce, PhD
Fellow


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Andrea Chow, PhD
VP, Measurement & Engineering


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William D. Shrader, PhD
Fellow


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Martin J. Thoolen, PhD
Chief Drug Development Officer


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Matthew Klein, MD, MS
Chief Medical Officer


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Jeff K. Trimmer, PhD
Senior VP, Discovery


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Peter P. Giannousis, PhD
Senior VP, Pharma Development & Manufacturing

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James C. Ostheimer, PhD
Associate Director, Data Science


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History & Mission

BioElectron is the culmination of over 30 years of work trying to understand a basic biochemical question—how does a single cell synchronize the one billion chemical reactions per second that comprise intermediary metabolism? 

Our work is built upon the foundational observations of Daniel E. Atkinson1 and others in the 1960-70’s who demonstrated that discrete energy parameters in living systems were highly regulated and conserved throughout the entirety of biology. But how? Where is the information system that regulates the core parameter of all living systems—energy—and how does it work? We have believed for 30 years that there is a missing information system in biology—one based on the dynamic energy parameters that underpin Atkinson’s observation. 

We now possess a first draft of that energy information system. It is comprised of enzymes and unappreciated redox small molecules that reversibly encode data in pi molecular orbitals to communicate information critical to the control of complex and dynamic biological systems. Our work has been accelerated by modern DNA-based tools. We identified this system by reverse-engineering diseases of energy metabolism—specifically, diseases caused by defects in enzymes that arise through genetic errors in mtDNA or nDNA. A significant byproduct of this work has been the development of drugs to treat children with mitochondrial diseases. These drugs are in active clinical development. We also possess a rich pipeline of other first-in-class targets, novel drug candidates, and paired diagnostics for a wide array of conditions; e.g., cancer, diabetes, aging, and Parkinson’s disease. These conditions share a common bioenergetic etiology—defects in electron-based (redox) communication. But the mission of BioElectron extends past these initial, important, and valuable advances about which we remain very passionate. Our Solutions span the life science and tech business ecosystems.

We now know a tremendous amount about the dynamic and complex electron wiring diagram that sits “beneath” Atkinson’s pioneering observation. BioElectron is the first hybrid biotech/tech platform company. Our focus is on the dynamic energy parameters within all living systems. We have devised new tools and new approaches to solving complex problems in biology which comprise our Platform. Today we are a multidisciplinary team—a Human Ecosystem—of over 75 individuals, including mathematicians, physicists, engineers, data scientists, computer engineers, chemists, enzymologists, molecular biologists, drug developers, and physicians. Our Mission is to learn how biological energy works to engineer solutions to complex, dynamic problems in biology.

 

1Daniel E. Atkinson, Cellular Energy Metabolism and its Regulation, 1977, Academic Press, p 1., Introduction

Biochemistry may be described as the study of living systems, using the methods of chemistry and physics. Life is a complex of interrelated chemical reactions. Even the structural features on which taxonomic classifications are mainly based are the products of chemical reactions. In any case, structure, since it survives nearly intact when a cell or organism dies, is clearly not life, although a high degree of structure is probably required for life. Disruption of the interrelated chemical activities of an organism is death; by the same token, these chemical activities, collectively, are life.”

Careers
We believe that great ideas originate from intelligent, driven and inspired individuals thriving in a culture of freedom, trust and creativity working to tackle problems that matter. We are a team of individuals, creating and working together to solve complex biological problems.
Director, Quality Assurance
Posted On October 18, 2017
Junior Graphic Designer
Posted On October 18, 2017
Associate Director/Director, Product Development
Posted On April 11th, 2017
Electrochemist
Posted On March 29th, 2017
Lab Technician / Research Assistant - Bioanalytical
Posted On January 19th, 2017
Group Leader - Oncology
Posted On January 12th, 2017
Research Associate II - Bioanalytical
Posted On January 19th, 2017
Research Associate III - Bioanalytical
Posted On January 19th, 2017
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Contact

BioElectron Technology Corporation
350 North Bernardo Avenue
Mountain View, CA 94043

info@bioelectron.com